Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function.

Adree Khondker, Joana Dos Santos, Samer Maher, Michael Chua, Armando J Lorenzo, Mandy Rickard

Abstract read

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Overview of pseudo-acute kidney injury.Renal failure · 2026
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Adree KhondkerDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3246-4662

Joana Dos SantosDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Samer MaherDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Michael ChuaDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Armando J LorenzoDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Mandy RickardDivision of Urology, Department of Surgery, The Hospital for Sick Children, Toronto, ON, Canada. Mandy.rickard@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrinary extravasation (UE) in patients with posterior urethral valves (PUV), in the form of urinomas or urinary ascites, is thought to represent a pop-off mechanism. Previous literature has proposed a kidney protective mechanism, although this remains controversial. Here, we performed a matched comparison to assess the effect of UE on kidney outcomes.

methodsWe retrospectively reviewed our PUV database, including all patients diagnosed < 3 months of age with at least 1-year follow-up. We collected demographics, management, vesicoureteral reflux (VUR) status, and kidney function parameters. UE was defined as postnatal urinoma or urinary ascites. We performed both unadjusted and propensity-matched comparisons of patients with and without UE. Matching was used to balance age, diversion status, urinary tract infection history, presence of VUR, and nadir creatinine. The primary outcomes were 1-, 3-, and 5-year kidney outcomes.

resultsOf the 138 patients meeting inclusion criteria, 27 (20%) had UE (23 urinoma, 4 urinary ascites). The median age at presentation was 5 days. Six patients (26%) required percutaneous drainage, and the median time to resolution was 21 days. Patients with UE had significantly higher initial creatinine levels but no difference in nadir values. Of those with available data, 18 (18%) and 10 (14%) had chronic kidney disease (CKD) at 3 and 5 years. Overall, there was no difference in 3- and 5-year rates of CKD between patients with and without a history of UE.

conclusionsIn a matched comparison, UE was not associated with long-term adverse or beneficial effects on kidney function. This study provides further evidence that the presence of UE may not be a relevant prognostic factor in children with PUV.

Indexed as

AscitesKidneyUrethraUrinomaFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleRetrospective StudiesVesico-Ureteral RefluxKidney functionPop-off mechanismPosterior urethral valveUrinary ascitesUrinoma

Identifiers

PMID41028498

DOI10.1007/s00467-025-06984-y

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