Evidence map›Paper›PMID 41028451›Full record

ReviewNature plants2025

Cross-kingdom mechanisms of trained immunity in plant systemic acquired resistance.

Uwe Conrath

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Uwe ConrathDepartment of Molecular Plant Physiology, RWTH Aachen University, Aachen, Germany. uwe.conrath@bio3.rwth-aachen.de.ORCID 0000-0002-8503-1943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants face constant microbial threats and have evolved highly effective immune systems characterized by inducible defence mechanisms. On recognizing microbial patterns and/or effectors, plants activate localized pattern-triggered immunity and/or effector-triggered immunity, which culminate in systemic acquired resistance-a broad-spectrum immune response that enhances protection throughout the plant. Systemic acquired resistance shares striking similarities with mammalian trained immunity, particularly in defence priming, which equips organisms with an enhanced capacity to respond to subsequent infections. This Review explores the cross-kingdom similarities between systemic acquired resistance and trained immunity, emphasizing their potential to transform agricultural practices and medical therapies. These insights present innovative opportunities for developing new plant-protection strategies, producing disease-resistant crops and optimizing vaccine approaches, while also highlighting critical knowledge gaps to inspire future research.

Indexed as

Adaptive ImmunityDisease ResistancePlant DiseasesPlant ImmunityPlantsCrops, AgriculturalPlant Systemic Acquired ResistanceTrained Immunity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.