Observational studyScientific reports2025
Evaluating the diagnostic significance of biomarkers in ventriculitis through a multivariate correlation study in a tertiary care center.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ventriculitis poses a critical risk in neurocritical care, requiring swift diagnosis for timely treatment. This study assessed the diagnostic value of cerebrospinal fluid biomarkers (IL-6, IL-10, TNF-α, procalcitonin (PCT), C-reactive protein (CRP), and CSF lactate) in conjunction with CSF microbial profiling and antimicrobial susceptibility in patients with ventriculitis. This prospective observational study was conducted from July 2023 to May 2024 at the Neuromicrobiology Department, National Institute of Mental Health and Neuroscience (NIMHANS) and analyzed cerebrospinal fluid from patients undergoing routine microbiological culture and sensitivity tests. The study involved 159 patients divided into control, probable, and confirmed ventriculitis groups. Standard methods were used for microbial isolation and antimicrobial susceptibility testing. Additionally, CSF biomarker levels were measured to provide deeper insights into patient conditions. Our study revealed elevated IL-6, IL-10, TNF-α, procalcitonin (PCT), C-reactive protein (CRP), and CSF lactate, levels in both confirmed and probable ventriculitis patients, with IL-6 being the most accurate diagnostic biomarker. Cerebral neoplasm was the most prevalent condition (44·1%), with headache as the primary symptom. Acinetobacter baumannii (39·4%), Escherichia coli (18·2%), and Klebsiella pneumoniae (15·2%) were the most common pathogens identified in CSF cultures. Acinetobacter baumannii and Klebsiella pneumoniae were identified as highly susceptible to colistin but showed significant resistance to carbapenems and variable resistance to other antibiotics. This study emphasizes the severe impact of ventriculitis and identifies IL-6, IL-10, and TNF-alpha as effective biomarkers for diagnosing ventriculitis, with high sensitivity, specificity, and diagnostic performance. Significant antibiotic resistance highlights the need for effective infection control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.