Evidence map›Paper›PMID 41028280›Full record

ArticleJournal of ophthalmic inflammation and infection2025

The relationship between retinal vascular tortuosity and retinal vasculitis.

Xiaoyan Zhang, Frances Andrea Anover, Jia-Horung Hung, Ngoc Trong Tuong Than, Azadeh Mobasserian, Aim-On Saengsirinavin, Negin Yavari, Dalia El Feky, Anh Ngoc Tram Tran, Osama Elaraby and 7 more

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In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaoyan ZhangSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Frances Andrea AnoverSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Jia-Horung HungSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Ngoc Trong Tuong ThanSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Azadeh MobasserianSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Aim-On SaengsirinavinSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Negin YavariSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Dalia El FekySpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Anh Ngoc Tram TranSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Osama ElarabySpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Jingli GuoSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Irmak KaracaSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Woong-Sun YooSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Amir AkhavanrezayatSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Chi Mong Christopher OrSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Diana V DoSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA.
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, USA. ndquan@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study investigates the association between retinal vascular tortuosity and retinal vasculitis.

methodsA retrospective review of medical records was conducted for 135 patients diagnosed with retinal vasculitis at our institution from June 2022 to June 2024. The presence and type of retinal vascular tortuosity were assessed, and logistic regression analysis was used to evaluate associations with viral infections, autoimmune conditions, and other clinical features.

resultsOf 256 patients with posterior uveitis, 135 patients were identified with retinal vasculitis, and 37 (27.4%) exhibited retinal vascular tortuosity. Specifically, 24 patients presented with arterial tortuosity, 5 with venous tortuosity, and 8 with both arterial and venous tortuosity. Logistic regression analysis revealed that arterial tortuosity was significantly associated with posterior synechiae, while venous tortuosity was primarily observed in patients with birdshot chorioretinopathy. Combined arterial and venous tortuosity was more commonly observed in patients with viral infections, toxoplasmosis, or psoriasis. Notably, after inflammation was controlled, retinal vascular tortuosity improved. However, the average recovery times varied between arterial tortuosity, venous tortuosity, and the combination of both.

conclusionRetinal vascular tortuosity is prevalent in retinal vasculitis and is associated with specific infectious etiologies and clinical features. It may serve as a prognostic marker for disease severity and treatment planning.

Indexed as

And retinal vasculitisArterial and venous tortuosityArterial tortuosityVenous tortuosity

Identifiers

PMID41028280
PMCPMC12484475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.