Evidence map›Paper›PMID 41028239›Full record

ArticleArchives of toxicology2026

Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity.

Jia Jin Hiu, Hock Siew Tan, Michelle Khai Khun Yap

Abstract read
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jia Jin HiuSchool of Science, Monash University Malaysia, Bandar Sunway, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Hock Siew TanSchool of Science, Monash University Malaysia, Bandar Sunway, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Michelle Khai Khun YapSchool of Science, Monash University Malaysia, Bandar Sunway, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia. yap.michelle@monash.edu.ORCID 0000-0002-9646-3944

Funding

Fundamental Research Grant Scheme FRGS/1/2023/SKK10/MUSM/02/4
6 · The paper itself

Abstract

Cytotoxin (CTX) is one of the major cobra venom components that contributes to dermonecrosis due to its cytotoxicity. However, current antibody-based antivenoms exert limited neutralisation effects against CTX-induced dermonecrosis. This study focused on discovering aptamer-based antivenom that specifically targets CTX, using repetitive centrifugation-based Systematic Evolution of Ligands by EXponential enrichment (SELEX) selection approach and Illumina amplicon next-generation sequencing. A total of 12 repetitive centrifugation-based selection rounds including a negative selection between rounds 7 and 8 were performed. This was followed by amplicon next-generation sequencing and sequencing bioinformatics workflow to analyse the abundance and persistence of the CTX-binding candidates. Sequences with log

Indexed as

AntiveninsAptamers, NucleotideCytotoxinsDNA, Single-StrandedElapid VenomsAnimalsHumansNaja najaSELEX Aptamer TechniqueAntiveninsAptamers, NucleotideCytotoxinsDNA, Single-StrandedElapid Venoms40TAptamerCytotoxicityNaja venomNeutralisation

Identifiers

PMID41028239
PMCPMC12858506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.