ArticleScientific reports2025
The introduction and evaluation of novel decellularized extracellular matrix/gellan gum bioprinting scaffolds for cartilage tissue engineering.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decellularized Extracellular Matrix/Gellan Gum Hydrogels Enriched with Spermine for Cardiac Models.Gels (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage demonstrated limited self-regeneration; and there is a need for developing new compounds. Here, gellan gum was selected due to its hydrophilicity, biocompatibility, and native cartilage environmental resemblance, and cartilage decellularized extracellular matrix (dECM) was added (GG/dECMb) to improve the cellular interactions. The decellularization was performed using freeze-thaw cycles and sodium dodecyl sulfate and a hematoxylin-eosin and Bradford assays showed successful decellularization with low extracellular matrix damage. The GG/dECMb compound was formulated, and the gellan gum was considered as the control (GGb). The rheological evaluations demonstrated the shear-thinning and bioprinting capability, while the GG/dECMb had a lower cross-linking degree (5.04 ± 0.79%) in comparison to GGb (6.65 ± 0.48%). Both bioinks were successfully bioprinted. The mechanical test demonstrated the GG/dECMb had a damping feature, which is essential for cartilage regeneration. Furthermore, it has a higher hydrophilic nature (44.27 ± 6.0° contact angle), swelling ratio, and biodegradation ratio in comparison to GGb. The cellular tests confirmed the high capability of GG/dECMb dried scaffolds in cell viability based on the cell viability test (97.41 ± 1.02%) and live/dead assays. The Alcian blue staining proved the glycosaminoglycans deposition and cartilage differentiation of GG/dECMb. Therefore, it seems that GG/dECMb can be effective in cartilage regeneration, although needs further in-vivo studies in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.