Evidence map›Paper›PMID 41028194›Full record

ArticleScientific reports2025

T cell dysregulation reflects disease stage in hepatitis virus and alcohol-related liver disease.

Christian Niehaus, Yin-Han Chou, Helena Lickei, Ayesha Lietzau, Roni Souleiman, Benjamin Maasoumy, Heiner Wedemeyer, Christine S Falk, Anke R M Kraft, Markus Cornberg

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christian NiehausDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Yin-Han ChouDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Helena LickeiDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Ayesha LietzauDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Roni SouleimanDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Benjamin MaasoumyDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Heiner WedemeyerDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Christine S FalkGerman Center for Infection Research (DZIF), Partner-Site Hannover-Braunschweig, Hannover, Germany.
Anke R M KraftDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Markus CornbergDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany. Cornberg.Markus@mh-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cirrhosis is characterized by both immunodeficiency and an exaggerated immune response leading to systemic inflammation. In this study, we investigated the role of T cells in different stages of liver disease and therefore analyzed 72 patients stratified into those with and without cirrhosis and compensated and decompensated cirrhosis. Flow cytometry revealed that CD8

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesLiver CirrhosisLiver Diseases, AlcoholicAdultAgedCD4-CD8 RatioCytokinesFemaleHumansMaleMiddle AgedCytokinesCirrhosis-associated immune dysfunctionCytokinesHepatitis virus infectionLiver cirrhosisSystemic inflammationT cells

Identifiers

PMID41028194
PMCPMC12485000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.