Evidence map›Paper›PMID 41027946›Full record

ArticleNature communications2025

A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.

Mingjie Zhou, Biao Yan, Fukui Yang, Chuxiang Chen, Fei Wang, Chenpei Xu, Tingzheng Jiang, Kexin Li, Yuanting Xie, Hao Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingjie Zhou *Department of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Biao Yan *Department of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0003-3252-2965
Fukui Yang *Sainsbury Wellcome Center, University College London, London, UK.ORCID http://orcid.org/0009-0000-7355-2859
Chuxiang Chen *Department of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Fei WangDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Chenpei XuDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Tingzheng JiangDepartment of Hand Surgery, Department of General Medicine, Huashan Hospital, Fudan University, Shanghai, PR China.
Kexin LiDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Yuanting XieDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Hao ZhengDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Chengyang WangMicroPort Neuronical MedTech (Shanghai) Co. Ltd., Shanghai, PR China.
Jiayi ZhangDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China. jiayizhang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1575-0723
Su JiangDepartment of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China. oscarjiangsu@126.com.ORCID http://orcid.org/0000-0001-9153-1066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve transfer is an effective surgical method in restoring motor functions of upper limb after peripheral nerve injuries. However, the outcome of individual function recovery is less predictable. It is crucial to access the long-term evaluation of function improvement. Here, we developed a fully implantable multisite optogenetic stimulation system, which is tailored for wireless, reprogrammable and long-term function evaluation of peripheral nerve plexus with sub nerve resolution. In Thy1-ChR2-EYFP mice, our system induced distinct compound muscle action potentials and forelimb movements when illuminating different nerve fascicles. Furthermore, we applied the system on a nerve transfer mice model after traumatic brain injury and discovered innervation pattern of the transferred and adjacent nerves to multiple muscles consecutively within 12 weeks after surgery. Our system enabled refined evaluation of electrophysiological and motor functions of peripheral nerve plexus, shining light upon personalized diagnosis and treatment after nerve injuries or surgeries.

Indexed as

ForelimbOptogeneticsPeripheral Nerve InjuriesPeripheral NervesWireless TechnologyAction PotentialsAnimalsBrain Injuries, TraumaticDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicRecovery of Function

Identifiers

PMID41027946
PMCPMC12484816

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.