Fourteen year retrospective study of craniofacial pain in a neurological emergency department.

Aleksandra Lučić, Zlatko Božić, Aleksandar Kopitović, Sanela Popović, Dane Krtinić, Igor Petrušić

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Aleksandra LučićFaculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, 21000, Serbia. aleksandra.lucic-prokin@mf.uns.ac.rs.ORCID http://orcid.org/0000-0002-3434-8684

Zlatko BožićFaculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, 21000, Serbia.

Aleksandar KopitovićFaculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, 21000, Serbia.

Sanela PopovićFaculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, 21000, Serbia.

Dane KrtinićDepartment for pharmacology and toxicology, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Đinđića 81, Niš, 18108, Serbia.

Igor PetrušićLaboratory for Advanced Analysis of Neuroimages, Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11158 Belgrade 118, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This fourteen-year retrospective cross-sectional study (August 2010 - July 2024) provides the first analysis of neuropathic craniofacial pain (CFP) in a neurological emergency department (ED), evaluating its types, characteristics, and management. Data from electronic medical records were analyzed using descriptive statistics and non-parametric tests (p < 0.05). Among 156 adult CFP patients (median age 61 years; female 108/156, 69.2%), six CFP types were identified, with trigeminal neuralgia (TN) being the most common (122/156, 78.2%), and etiologically defined in 30/122 patients (24.6%). The typical patient was an elderly female with severe, right-sided TN affecting the V2 and V3 branches. Acute treatment lacked guideline-supported rapid-onset options, relying instead on nonopioid and opioid analgesics (48/54 patients, 88.9%). There was a decline in cases after the beginning of the COVID-19 pandemic (p = 0.001). Rare CFPs and their combinations can initially present in the ED, where diagnostic complexity and treatment gaps pose significant challenges. These findings highlight the ED's critical role and the need for institutional guidelines based on ICHD-3 or ICOP to improve CFP management.

Indexed as

Emergency Service, HospitalFacial PainTrigeminal NeuralgiaAdultAgedAged, 80 and overCOVID-19Cross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesCross-Sectional studiesEmergency service, hospitalFacial painPain managementTrigeminal neuralgia

Identifiers

PMID41027942

DOI10.1038/s41598-025-01246-1

PMCPMC12484931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.