Evidence map›Paper›PMID 41027929›Full record

ArticleNPJ breast cancer2025

Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers.

Mei-Chee Tai, Joe Dennis, Sue K Park, Sung-Won Kim, Jong Won Lee, Nur Tiara Hassan, Ava Kwong, Mikael Hartman, Sook-Yee Yoon, Joanne Ngeow and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Mei-Chee TaiCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.
Sung-Won KimDepartment of Surgery, Daerim St. Mary's Hospital, Yeongdeungpo-gu, Seoul, Korea.
Jong Won LeeDepartment of Surgery, Ulsan College of Medicine and Asan Medical Center, Songpa-Gu, Seoul, Korea.
Nur Tiara HassanCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Ava KwongCancer Genetics Centre and Breast Surgery Centre, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong.
Mikael HartmanDepartment of Surgery, National University Hospital and National University Health System, Singapore, Singapore.
Sook-Yee YoonCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Joanne NgeowCancer Genetics Service, National Cancer Centre Singapore, Singapore, Singapore.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Boyoung ParkDepartment of Preventive Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Zhi-Lei WongCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Goska LeslieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Daniel R BarnesCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Michael T ParsonsPublic Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Penny SoucyGenomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada.
Jacques SimardGenomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada.
Nur Aishah Mohd TaibDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Cheng-Har YipSime Darby Medical Centre, Subang Jaya, Selangor, Malaysia.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Georgia Chenevix-TrenchDepartment of Haematology-Oncology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA, Australia.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Soo-Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Weang-Kee HoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia. WeangKee.Ho@nottingham.edu.my.

Funding

Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
NCI NIH HHS R01 CA128978NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537Wellcome TrustWellcome Trust v203477/Z/16/ZWellcome Trust Career Development Award 227824/Z/23/Z (UNS146816)
6 · The paper itself

Abstract

Polygenic risk scores (PRS) have been shown to be predictive of breast cancer (BC) risk in European BRCA1 and BRCA2 pathogenic variant (PV) carriers, but their utility in Asian populations has not been evaluated. In this study, we evaluated the association of two breast cancer PRS developed for the East Asian general population and three versions of a PRS developed for the European general population in 604 BRCA1 (390 affected by breast cancer) and 785 BRCA2 (552 affected by breast cancer) PV female carriers of Asian ancestry. Only the Asian-based PRS, constructed using approximately 1 million single-nucleotide variations (SNVs), showed a significant association with breast cancer risk (Hazard Ratio per standard deviation (95% Confidence Interval) is 1.47 (1.10-1.95) for BRCA1 and 1.43 (1.04-1.95) for BRCA2). Incorporating this PRS into risk prediction models may improve cancer risk assessment among PV carriers of Asian ancestry.

Identifiers

PMID41027929
PMCPMC12484999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.