Medication reconciliation and drug interactions in adult cystic fibrosis patients attending an outpatient clinic: A Cross-sectional study.

Outpatient medication reconciliation (MR) studies in adult cystic fibrosis (CF) patients are scarce. This project aims to evaluate outpatient MR in adult CF individuals and to identify the prevalence of discrepancies and describe associated factors. Additionally, the study examines drug-drug interactions (DDI) and challenges in accessing medications. It's a cross-sectional study with prospective data collection, involving 65 participants. The sample was divided into two groups based on discrepancies: Group 1 (0-1 discrepancy) included 26 (40%) individuals, and Group 2 (2 or more discrepancies) had 39 (60%). The median number of medications used was 9. Thirty-five patients (53.8%) used medications prescribed only by the CF outpatient clinic, while 30 (46.2%) also had external prescriptions. Fifty-two patients (80%) engaged in self-medication. The number of medications was significantly higher in Group 2 than in Group 1 (median of 11.0 vs. 7.5, p = 0.003). Self-medication was more common in Group 2 (92.3% vs. 61.5%, p = 0.006). Fourteen patients (21.5%) had serious DDIs (type X), and 26 (40%) had type D DDIs. External prescriptions were significantly associated with serious DDIs. Most patients reported difficulty accessing medications. A high prevalence of discrepancies (83%) was observed, linked to the number of medications and self-medication.