ArticleNature communications2025
A doubly stochastic renewal framework for partitioning spiking variability.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Partitioning Neural Co-Variability.ArXiv · 2026Article
- Continuous partitioning of neuronal variability.bioRxiv : the preprint server for biology · 2025Article
- Article
- Brain-wide organization of intrinsic timescales at single-neuron resolution.bioRxiv : the preprint server for biology · 2025Article
- Poisson Variational Autoencoder.ArXiv · 2024Article
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3 authors.
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Abstract
The firing rate is a prevalent concept used to describe neural computations, but estimating dynamically changing firing rates from irregular spikes is challenging. An inhomogeneous Poisson process, the standard model for partitioning firing rate and spiking irregularity, cannot account for diverse spike statistics observed across neurons. We introduce a doubly stochastic renewal point process, a flexible mathematical framework for partitioning spiking variability, which captures the broad spectrum of spiking irregularity from periodic to super-Poisson. We validate our partitioning framework using intracellular voltage recordings and develop a method for estimating spiking irregularity from data. We find that the spiking irregularity of cortical neurons decreases from sensory to association areas and is nearly constant for each neuron under many conditions but can also change across task epochs. Spiking network models show that spiking irregularity depends on connectivity and can change with external input. These results help improve the precision of estimating firing rates on single trials and constrain mechanistic models of neural circuits.
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