ReviewBiomolecules & therapeutics2025
Transforming Pain Management: Suzetrigine, a Novel Non-Opioid Analgesic.
Review in Biomolecules & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Small-Molecule Drugs Approved by the FDA in 2025.Molecules (Basel, Switzerland) · 2026Review
- Selective NaV1.8 Inhibition for Pain Management: Current Evidence and Future Potential of Suzetrigine.Current pain and headache reports · 2026Review
- The real-world safety evaluation of the selective NaV1.8 inhibitor suzetrigine: disproportionality analysis and flexible empirical bayes signals from FAERS with external triangulation.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suzetrigine is a novel non-opioid analgesic that selectively inhibits the Nav1.8 sodium channel, which plays a key role in peripheral pain signaling. By blocking action potential propagation in nociceptors, it effectively reduces pain without affecting the central nervous system, thus avoiding the risks associated with opioids, such as addiction and respiratory depression. In two phase 2 clinical trials, suzetrigine demonstrated superior pain control compared to placebo and showed comparable effectiveness to hydrocodone/acetaminophen for treating moderate to severe acute pain after abdominoplasty and bunionectomy with an acceptable safety profile. Current findings support suzetrigine's potential role as a safer alternative to opioids in managing moderate to severe pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.