Evidence map›Paper›PMID 41027851›Full record

ArticleMedical physics2025

Diffusing alpha-emitters radiation therapy: In vivo measurements of effective diffusion and clearance rates across multiple tumor types.

Mirta Dumančić, Guy Heger, Ishai Luz, Maayan Vatarescu, Noam Weizman, Lior Epstein, Tomer Cooks, Lior Arazi

Abstract read
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mirta DumančićMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Guy HegerUnit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Ishai LuzThe Shraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Maayan VatarescuThe Shraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Noam WeizmanUnit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Lior EpsteinUnit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Tomer CooksThe Shraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Lior AraziUnit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.

Funding

Alpha TAU Medical Ltd
6 · The paper itself

Abstract

backgroundDiffusing alpha-emitters radiation therapy ("Alpha-DaRT") is a new modality that uses alpha particles to treat solid tumors. Alpha-DaRT employs interstitial sources loaded with low activities of PURPOSE: The aim of this work is to estimate the tumor-specific parameters of the DL model from in vivo studies on multiple histological cancer types.

methodsAutoradiography studies with phosphor imaging were conducted on 113 tumors in mice from 10 cancer cell lines. An observable, referred to as the "effective diffusion length"

resultsThe measured values of

conclusionsThe measured values of

Indexed as

Alpha ParticlesNeoplasmsRadiotherapyAnimalsCell Line, TumorDiffusionHumansMiceRadiometryalpha dose calculationsalpha‐radiopharmaceutical therapybrachytherapyDaRTtargeted alpha therapy

Identifiers

PMID41027851
PMCPMC12483980

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.