ArticleMedical physics2025
Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicronuclei (MN), which are chromosome fragments, are formed after exposure to ionizing radiation. Radiation-induced MN is currently used as a quantitative indicator of the chromosomal aberrations detectable at a relatively early phase (e.g., within one cell-cycle progression). Meanwhile, the MN formation assay is also used to evaluate radiosensitivity (e.g., cell-killing). As such, the technique to assay the MN formation has been followed with increasing interest. However, the meaning of MN and the corresponding cellular responses remains uncertain. PURPOSE: This study presents a biophysical model for estimating MN frequency and theoretically explores the cellular responses associated with MN formation, such as the relationship between MN formation and cell survival.
methodsWe used an integrated microdosimetric-kinetic (IMK) model that allows the prediction of cell survival after radiation exposure, and we extended the IMK model by introducing a probability of MN formation from lethal lesions by misrepair. To validate the developed model, we estimated the dose, linear energy transfer (LET), and dose-rate dependencies of MN frequency as well as its relative biological effectiveness (RBE
resultsOur developed IMK model enables the prediction of the MN formation frequency and the RBE
conclusionsThe present model indicates that the analysis of MN is useful in both radiation therapy and radiation protection to quantitatively evaluate curative effects and histological damage at early stages after exposure.
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