Evidence map›Paper›PMID 41027692›Full record

ArticleBMJ open2025

The effects of oliceridine and sufentanil on postoperative nausea and vomiting in abdominal surgery (EOSPONVAS): protocol for a multicentre, two-arm, randomised controlled trial.

Jie Luo, Lizhen Wang, Zhongping Jie, Yang Li, Changzhen Geng, Panpan Li, Tong Wang, Yaping Shi, Xiaohua Fan, Lijun Zhang and 1 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie Luo *Department of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0000-0002-4055-568X
Lizhen Wang *Department of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0003-9120-7321
Zhongping Jie *Department of Anesthesiology, Wusong Central Hospital of Shanghai,Baoshan, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0008-8756-6678
Yang LiDepartment of Anesthesiology, Shanghai Public Health Clinical Center, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0004-4296-4585
Changzhen GengDepartment of Anesthesiology, Shanghai Public Health Clinical Center, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0003-6854-9542
Panpan LiDepartment of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0003-3961-8377
Tong WangDepartment of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0009-0009-3210-9215
Yaping ShiDepartment of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0000-0002-3192-5802
Xiaohua FanDepartment of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.ORCID http://orcid.org/0000-0002-7994-6776
Lijun Zhang *Department of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China xutaosci@163.com zhanglijun_ch2002@163.com.ORCID http://orcid.org/0009-0000-5796-7333
Tao Xu *Department of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China xutaosci@163.com zhanglijun_ch2002@163.com.ORCID http://orcid.org/0000-0002-5778-5676

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOliceridine is a novel μ-opioid receptor selective agonist that provides analgesia while reducing μ-receptor-mediated adverse effects such as postoperative nausea and vomiting (PONV). Evidence in abdominal surgery remains limited. This study aims to determine whether oliceridine reduces PONV and improves recovery in abdominal surgery. METHODS AND ANALYSIS: This is a prospective, multicentre, two-arm, randomised trial. Participants aged 18-65 years, with American Society of Anesthesiologists physical status I-III and a body mass index of 18.5-23.9 kg/m², undergoing elective major abdominal surgery, will be eligible for inclusion. Gynaecological surgeries are excluded. All patients must require postoperative intravenous patient-controlled analgesia (PCIA) and give written consent. 494 participants will be randomised to oliceridine group or sufentanil group. The primary outcome is the incidence of PONV within 48 hours postsurgery. Secondary outcomes include vomiting frequency, nausea severity score, use of rescue antiemetics, resting numerical rating scale (NRS) pain score, Quality of Recovery-15 (QoR-15) score, time to first postoperative flatus, intensive care unit (ICU) length of stay (LOS), hospital LOS and PCIA metrics (effective attempts and total volume used). Safety outcomes include other opioid-related adverse effects (ORAEs) (eg, respiratory depression, pruritus, dizziness, headache), complications related to PONV (eg, electrolyte disturbances, wound dehiscence) and other perioperative complications. ETHICS AND DISSEMINATION: This protocol was approved (Version V3.0, 2025-01-14) by the Ethics Committee of Changhai Hospital (CHEC-2025-069), the Shanghai Public Health Clinical Centre (2025-S024-01) and the Wusong Central Hospital of Baoshan District, Shanghai (2025-17-01). It complies with the Declaration of Helsinki. Results will be shared via conferences and peer-reviewed journals. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry (ID: ChiCTR2400089262).

Indexed as

AbdomenAnalgesics, OpioidAntiemeticsPostoperative Nausea and VomitingSufentanilAdolescentAdultAgedAnalgesia, Patient-ControlledFemaleHumansMaleMiddle AgedMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicAnalgesics, OpioidAntiemeticsSufentanilAdult anaesthesiaColorectal surgeryHepatobiliary surgeryPain managementPancreatic surgery

Identifiers

PMID41027692
PMCPMC12506128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.