Evidence map›Paper›PMID 41027580›Full record

ArticleThe Journal of infectious diseases2026

Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies.

Kavita Panwar, Kazutomo Yokoya, Sofia Gomes, Vanessa Tenet, John Schussler, Rolando Herrero, Lisa Mirabello, John T Schiller, Mónica S Sierra, Gary M Clifford and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kavita PanwarVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, United Kingdom.
Kazutomo YokoyaVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, United Kingdom.ORCID 0000-0002-5280-185X
Sofia GomesVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, United Kingdom.
Vanessa TenetEarly Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0009-0003-0428-3116
John SchusslerInformation Management Services Inc, Silver Spring, Maryland.ORCID 0000-0002-8793-0766
Rolando HerreroAgencia Costarricense de Investigaciones Biomédicas, formerly Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica.ORCID 0009-0001-3826-6176
Lisa MirabelloDivision of Cancer Epidemiology and Genetics.ORCID 0000-0001-8485-0106
John T SchillerCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Mónica S SierraDivision of Cancer Epidemiology and Genetics.
Gary M CliffordEarly Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, France.
Simon BeddowsVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, United Kingdom.ORCID 0000-0002-6879-6215

Funding

NCI NIH HHS N01 CP011005UK Health Security Agency; the Intramural Research Program of the National Institutes of Health;World Health Organization 001
6 · The paper itself

Abstract

Human papillomavirus variants are classified into lineages based on their whole genome sequence, but the impact of lineage variation on the structure or function of encoded proteins is unclear. We used a global panel of lineage-specific natural infection sera to assess antibody-binding specificity for lineage-specific L1L2 antigens, and we used these data to create relational antigenic maps. Merging these data with neutralizing antibody data demonstrated similar spatial geometry and revealed dependency on a limited number of amino residues on the capsid surface. These data inform the degree of lineage specificity within the natural infection humoral immune response to oncogenic human papillomaviruses.

Indexed as

Antibodies, ViralAntigens, ViralCapsidCapsid ProteinsPapillomaviridaePapillomavirus InfectionsAntibodies, NeutralizingHuman Papillomavirus VirusesHumansAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCapsid ProteinsantibodyantigenHPVlineagenatural infection

Identifiers

PMID41027580
PMCPMC12811858

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.