Evidence map›Paper›PMID 41027427›Full record

ArticleDevelopmental cell2026

Non-cell-autonomous tumor promotion in DICER1 cancer predisposition.

Randolph K Larsen, Jason A Hanna, Hongjian Jin, Kristin B Reed, Darden W Kimbrough, Kyna Vuong, Jongchan Hwang, Grace E Adkins, Jack D Hopkins, Bradley T Stevens and 12 more

Abstract read
In one paragraph

Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cell-type Specific Alteration ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Randolph K LarsenSt. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA.
Jason A HannaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hongjian JinCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kristin B ReedDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Darden W KimbroughDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kyna VuongDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA; St. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA.
Jongchan HwangDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Grace E AdkinsSt. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA.
Jack D HopkinsDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bradley T StevensSt. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA.
Myron K EvansDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Casey G LangdonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Catherine J DrummondDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Matthew R GarciaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kristin B WigginsSt. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Amy R IversonDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
David FinkelsteinDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Patrick A SchreinerCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jason W RoschDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jerold E RehgDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kris Ann P SchultzCancer and Blood Disorders, Children's Minnesota, Minneapolis, MN, USA; International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA; International Ovarian and Testicular Stromal Tumor Registry, Children's Minnesota, Minneapolis, MN, USA.
Mark E HatleyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA; St. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA. Electronic address: mark.hatley@stjude.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Defining the non-myogenic origins of pediatric rhabdomyosarcomaR01CA216344 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HATLEY, MARK EDWARD · 2017 to 2021
$2.0M
Mediators Of Arrested Differentiation In Pediatric RhabdomyosarcomaR01CA251436 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HATLEY, MARK EDWARD · 2021 to 2025
$2.0M
Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
Dissecting the role of tumor suppressing microRNAs in angiosarcomaR01CA299902 · NCI · PURDUE UNIVERSITY · PI Jason A. Hanna · 2026 to 2026
$438k
Determining the Mechanism of Rhabdomyosarcoma Transformation from a Non-Myogenic Cell of OriginF31CA290924 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC · PI Grace Elizabeth Adkins · 2025 to 2026
$98k
NCI NIH HHS F31 CA290924NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA216344NCI NIH HHS R01 CA251436NCI NIH HHS R01 CA299902NCI NIH HHS R50 CA221675
6 · The paper itself

Abstract

DICER1-related tumors are characterized by germline loss-of-function mutations in one DICER1 allele (DICER1

Indexed as

DEAD-box RNA HelicasesGenetic Predisposition to DiseaseNeoplasmsRhabdomyosarcomaRibonuclease IIIAnimalsCarcinogenesisFemaleGerm-Line MutationHumansMiceMice, Inbred C57BLNeutrophilsDEAD-box RNA HelicasesDICER1 protein, humanDicer1 protein, mouseRibonuclease IIIcancer predispositionDICERDICER1microRNANETosisneutrophilPADI4pediatric cancerrhabdomyosarcomasarcoma

Identifiers

PMID41027427
PMCPMC12614631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.