ArticleDrug metabolism and disposition: the biological fate of chemicals2025
Pharmacogenetics of steady-state metabolism, pharmacokinetics, and adverse effects of voriconazole in healthy participants.
Article in Drug metabolism and disposition: the biological fate of chemicals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The evolving landscape of pharmacogenomics: Current achievements and future directions.Pharmacological reviews · 2026Review
- Voriconazole-associated adverse drug reactions in Chinese patients: incidence, clinical features and the predictive value of ALBI score for hepatotoxicity.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Voriconazole, a broad-spectrum antifungal, exhibits significant interpatient variability in efficacy and safety. This study assessed the influence of genetic and nongenetic factors on its steady-state pharmacokinetics and adverse effects. In vitro studies characterized voriconazole metabolism. An ancillary analysis was conducted on data from a completed trial involving 61 healthy participants who received a loading dose of 400 mg twice daily on first day, followed by 200 mg twice daily for 8 days. On the third day of voriconazole treatment, plasma and urine samples were collected over a 12-hour period after dose administration. Multiple trough concentrations, adverse events, and laboratory values were recorded throughout the study. Voriconazole and its metabolites were quantified using liquid chromatography-tandem mass spectrometry methods. Genotyping for CYP2C9, CYP2C19, CYP3A4, and CYP3A5 variants was performed using TaqMan assays. In vitro, CYP2C19 predominantly catalyzed the formation of voriconazole N-oxide and methyl hydroxy voriconazole, whereas CYP3A4/5 catalyzed fluoropyrimidine ring hydroxylation. Steady-state voriconazole area under the concentration-time curve (AUC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.