ArticleJMIR medical informatics2025
Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database.
Article in JMIR medical informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a common chronic respiratory disease with increasing prevalence among children over the past few decades. It can cause significant respiratory symptoms and acute exacerbations, often requiring emergency care or hospitalization. Moreover, exposure to respiratory viral infections, such as COVID-19 and influenza, can trigger severe complications in children with asthma. Despite these concerns, few studies have directly compared the in-hospital outcomes of children with asthma experiencing these infections.
objectiveThis study aimed to compare the in-hospital outcomes of these infections in children with asthma from a population-based perspective.
methodsWe conducted a population-based retrospective cohort study using data from the 2020 US Nationwide Readmissions Database. Children aged 1 to 19 years with asthma who were admitted for COVID-19 or influenza were eligible for inclusion. Outcomes evaluated included in-hospital mortality, major complications, and 90-day readmission rate. Survey-weighted logistic regression models were used to compare clinical outcomes between the two infection groups, adjusting for demographic and clinical characteristics.
resultsA total of 1472 hospitalized children with asthma were included, of whom 405 (27.5%) were admitted for COVID-19 and 1067 (72.5%) for influenza. After adjustment, the multivariate analysis revealed that children admitted for COVID-19 had a significantly higher risk of sepsis or shock (adjusted odds ratio [aOR] 4.30, 95% CI 1.79-10.32) but a lower risk of bacterial or fungal pneumonia (aOR 0.37, 95% CI 0.23-0.61) compared with those admitted for influenza. Stratified analyses by age revealed that among children aged 1 to 5 years, the risk of 90-day readmission was significantly higher for those with COVID-19 than for those with influenza (aOR 3.02, 95% CI 1.09-8.35). No significant difference in in-hospital mortality was detected between the two infection groups in either the multivariable model or any of the age-stratified analyses.
conclusionsUS children with asthma hospitalized for COVID-19 had higher risks of sepsis or shock compared to those admitted for influenza. In contrast, children admitted for influenza had a higher risk for bacterial or fungal pneumonia. After stratifying by age, children aged 1 to 5 years with COVID-19 had a significantly higher risk of 90-day readmission than those with influenza. Our findings suggest that different clinical approaches may be needed for children with asthma, depending on infection etiology and patient age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.