Evidence map›Paper›PMID 41027016›Full record

ArticleCritical care explorations2025

Understanding the Outcomes of Extracorporeal Membrane Oxygen Support in Patients With Sickle Cell Trait.

Kate M Willsey, Michael E Plazak, Leonid Belyayev, Joseph Rabin, Janhavi Athale, Nancy Kim, Mark T Gladwin, Alison Grazioli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kate M WillseyUniversity of Maryland School of Medicine, Baltimore, MD.
Michael E PlazakDepartment of Pharmacy, University of Maryland Medical Center, Baltimore, MD.
Leonid BelyayevDivision of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Joseph RabinDepartment of Surgery and Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD.
Janhavi AthaleDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD.
Nancy KimDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Mark T GladwinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Alison GrazioliDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of common hemoglobinopathies, such as sickle cell trait (SCT), on outcomes in adults requiring extracorporeal membrane oxygenation (ECMO) remains understudied. Extracorporeal Life Support Organization registry data was analyzed to assess outcomes of adults with SCT or sickle cell disease (SCD) who underwent venoarterial or venovenous ECMO. Among 215 patients identified, 49 had SCT and 166 had SCD. The prevalence of SCT appeared grossly underestimated. Age-adjusted survival rates for SCT patients were favorable compared with those with SCD for venoarterial (43.5% vs. 19.5%; p = 0.04) and venovenous (73.3% vs. 44.8%; p = 0.11) ECMO. Bleeding and thrombotic event rates and renal complications in SCT patients were comparable to those with SCD and similar to reported rates in general adult ECMO populations. While our findings suggest that ECMO may be safely used in patients with SCT, further investigation is essential to determine the clinical impact of sickle cell and other hemoglobinopathies on ECMO therapy.

Indexed as

Extracorporeal Membrane OxygenationSickle Cell TraitAdultAnemia, Sickle CellFemaleHumansMaleMiddle AgedRegistriesSurvival RateTreatment Outcomeextracorporeal membrane oxygenationhemoglobinopathyhemolysismortalitysickle cell trait

Identifiers

PMID41027016
PMCPMC12487931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.