ArticleCritical care explorations2025
Sepsis and the Heart: In the Quest for Noninvasive Pressure-Volume Loops at the Bedside.
Article in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Reading discordant bedside indices in sepsis-induced cardiomyopathy: an evidence-mapping framework for diagnosis and trial design.Frontiers in cardiovascular medicine · 2026Review
- Clinical relevance of ventriculo-arterial coupling and how to assess it at the bedside.Annals of intensive care · 2026Article
- Dynamics of ventriculo-arterial coupling and peripheral tissue perfusion during early resuscitation of septic shock.Annals of intensive care · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-induced cardiomyopathy (SICM) is prevalent yet remains difficult to diagnose using conventional echocardiography primarily due to its dependence on loading conditions, the dynamic nature of sepsis, and varied cardiovascular phenotypes. Recent advancements in noninvasive myocardial work (MW) analysis, particularly through left ventricle pressure-strain loop (LV PSL), offer a promising strategy for evaluating myocardial function by combining strain imaging with blood pressure data. This technique may address the limitations inherent in traditional measures such as ejection fraction, which can be influenced by fluctuating hemodynamics in sepsis and may not accurately reflect underlying myocardial function. CASE SUMMARY: This report presents three cases wherein patients exhibited either preserved or only mildly reduced left ventricular systolic function based on ejection fraction (LVEF), but were found to have diminished MW indices, including global work index, global constructive work, and global work efficiency along with low flow by left ventricle outflow-tract.
conclusionsRelying solely on LVEF for diagnosing SICM is problematic due to numerous confounding variables. MW parameters constitute innovative, noninvasive echocardiographic indicators that have demonstrated value across a spectrum of cardiac disorders. Although these parameters appear promising as bedside assessment tools, their application within the context of sepsis warrants further investigation.
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