Trial reportDiabetes/metabolism research and reviews2025
Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.
Trial report in Diabetes/metabolism research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.Diabetes/metabolism research and reviews · 2025Trial
- The Role of Anti-Inflammatory Nutrition in Metabolic Syndrome and Cardiometabolic Diseases.Nutrients · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundIn older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.
objectiveTo evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.
methodsIn this clinical trial, 86 women aged 65-85 years with obesity (BMI ≥ 30 kg/m
resultsA significant reduction in waist circumference was observed over time in the FEHC group (p = 0.037), whereas no changes were detected in body weight, BMD or bone microarchitecture. Compared to FCD, the FEHC group showed reduced circulating IL-6 (p = 0.03), IL-8 (p = 0.022) and TNFα (p = 0.04) levels, along with lower IL-6 gene expression in muscle (p = 0.035). A strong trend of increased IGF-1 gene expression in muscle tissue of the FEHC group was also observed (p = 0.058). Gene expression analyses revealed a significant increase in WNT5a expression in muscle (p = 0.049), and an upward trend in WNT10b expression in bone (p = 0.055) while serum levels of DKK-1 were significantly higher in the FEHC group compared to FCD (p < 0.0001).
conclusionThe FEHC diet reduces systemic and local inflammation, without affecting skeletal health in older adults with obesity.
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