ReviewAnnual review of psychology2026
Early Life Stress Effects on Children's Biology, Behavior, and Health: Evidence, Mediators, Moderators, and Solutions.
Review in Annual review of psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Multilevel Effects of Socioeconomic Factors on the Somatic Status of Contemporary Youth Across Russian Regions.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- Growing in the Shadow of Mental Illness: Quality of Life, Health Status, Social Functioning, and Health Care Utilization Among Adults to Parents With Severe Mental Illness.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Article
- Families Implementing Resilient Systems Together (FIRST).Children (Basel, Switzerland) · 2026Article
- Factors associated with the mental health of parents during and after their child's hospitalisation: an international longitudinal prospective cohort study.BMJ mental health · 2026Article
- The associations between emotional neglect and positive mental health: the mediating role of stress-is-enhancing mindset and the moderating role of stress-is-debilitating mindset.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This review synthesizes and critiques research on early life adversity and stress effects on multidomain health outcomes in child samples to fill a gap in the literature that has largely focused on adults. Prioritizing evidence from meta-analytic and systematic reviews as well as findings from (quasi-)experimental or large prospective longitudinal studies, we integrate interdisciplinary findings to characterize patterns of evidence for stress associations with child outcomes, including mental, physical, and positive health; academic, social, and justice system-related domains; and intermediary phenotypes that may predict disease, including biomarkers. We note cohesive evidence for sensitive periods of susceptibility to stress exposure and describe key mediators and moderators of stress effects, especially family-level factors. Then we highlight interventions targeting malleable factors that hold promise for ameliorating the effects of stress on children. Leveraging a developmental lens, we conclude with field-wide limitations and propose future directions for stress and health research that centers child development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.