Evidence map›Paper›PMID 41026884›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia.

Natalia M Weinzierl, Jayarani Putri, Kathryn M Spitler, Erin E Talbert

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Natalia M WeinzierlDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.
Jayarani PutriDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.
Kathryn M SpitlerDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-0062-9613
Erin E TalbertDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-4587-0950

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
The Extracellular Matrix in Muscle AtrophyR00AR071508 · NIAMS · UNIVERSITY OF IOWA · PI TALBERT, ERIN E · 2020 to 2022
$737k
Sex-dependent rescue of cancer cachexiaR21CA257972 · NCI · UNIVERSITY OF IOWA · PI TALBERT, ERIN E · 2021 to 2021
$397k
HHS | NIH | National Cancer Institute (NCI) P30CA086862HHS | NIH | National Cancer Institute (NCI) R21CA257972HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R00AR071508HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK112751Iowa Office of Undergraduate Research N/ANCI NIH HHS P30 CA086862NCI NIH HHS R21 CA257972NIAMS NIH HHS R00 AR071508NIDDK NIH HHS T32 DK112751
6 · The paper itself

Abstract

Cancer cachexia, a multifactorial condition resulting in muscle and adipose tissue wasting, reduces the quality of life of many people with cancer. Cachexia is highly prevalent in people with pancreatic ductal adenocarcinoma (PDAC), and many animal models of pancreatic cancer are used to understand the mechanisms underlying cachexia. One such model is the

Indexed as

CachexiaPancreatic NeoplasmsAdipose TissueAnimalsBody WeightDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalSex CharacteristicsTamoxifenTamoxifencachexiadevelopmentmouse modelssexual dimorphism

Identifiers

PMID41026884
PMCPMC12590564

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.