ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025
Urine organic anion increases with age and its effects on renal acid excretion vary with pKa.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Findings of falling urine pH with age among stone formers have not been explained by changes in renal function or renal ammonia production with age. We collected and analyzed 245 urine samples from 190 stone-forming subjects (95 male) and 55 normal subjects (18 male) to expand on our previous study using urine titration to explore whether urine organic anion (Uoa) contributes to acid load and rises with age. We stratified our previous titration protocol to include three pKa subranges, 2.70-3.60, 3.61-4.30, and 4.31-7.40, to measure effects of Uoa of differing pKa values on renal acid excretion. We found that Uoa behaves as a metabolic acid, and associates independently and positively with ammonia (
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