Evidence map›Paper›PMID 41026635›Full record

ReviewAnalytical chemistry2025

Micro-Analytical Lab-on-a-Tip: Advances and Perspectives.

Panagiota M Kalligosfyri, Shohreh Madani, Antonella Miglione, Wanda Cimmino, Stefano Cinti, Amir Hatamie

Abstract readReview
In one paragraph

Review in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Panagiota M KalligosfyriDepartment of Pharmacy, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-8287-059X
Shohreh MadaniDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran.ORCID 0009-0003-2915-1590
Antonella MiglioneDepartment of Pharmacy, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-7531-1159
Wanda CimminoDepartment of Pharmacy, University of Naples Federico II, Naples 80131, Italy.
Stefano CintiDepartment of Pharmacy, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-8274-7452
Amir HatamieDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran.ORCID 0000-0002-7085-893X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid advancement of miniaturized analytical tools has revolutionized modern chemical analysis, with pipet tip-based sensors emerging as versatile, low-cost, and portable platforms for on-site detection. By repurposing standard plastic pipet tips as microreactors or sensor holders, these devices integrate electrochemical and optical elements to support applications in biomedical diagnostics, environmental monitoring, and food safety. Recent innovations include the incorporation of microelectrodes, nanomaterials, and 3D-printed components, enabling highly sensitive electroanalysis with minimal sample and reagent consumption. Optical systems, such as colorimetric and fluorescence-based assays, further enhance functionality by allowing rapid, visually interpretable, and multiplexed detection of ions, biomolecules, nucleic acids, and synthetic additives. Approaches based on filter paper, hydrogels, polymer networks, and additive manufacturing techniques have expanded the functional versatility of these devices by supporting sample filtration, reagent storage, and controlled reactions. Smart materials and magnetic separation further improve selectivity and sensitivity, while integration with smartphones enables real-time, decentralized diagnostics. These lab-on-a-tip systems align with green analytical chemistry principles by reducing chemical waste and promoting sustainable, user-friendly practices. Their affordability, ease of use, and adaptability make them especially valuable in resource-limited settings. This perspective presents a comprehensive overview of recent developments in pipet tip-based analytical devices, highlighting their transformation from simple laboratory tools into multifunctional sensing platforms. By summarizing key trends, design strategies, and practical applications, it underscores their pivotal role in shaping next-generation, environmentally friendly, and accessible point-of-care technologies.

Indexed as

Lab-On-A-Chip DevicesElectrochemical TechniquesHumans

Identifiers

PMID41026635
PMCPMC12529465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.