ArticleJournal of the American Chemical Society2025
(Salen)Metal-Catalyzed β-Glucuronidation of Alcohols, Phenols, and Anilines.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Iron Porphyrin Catalysts Induce Stereospecific Glycosylation with Glycal Epoxides.Synlett : accounts and rapid communications in synthetic organic chemistry · 2026Article
- Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides.Organic letters · 2026Article
- Iron-Catalyzed Stereospecific HeterocycleResearch square · 2026Article
- Merging Enzymatic Catalysis with Iron Catalysis for Highly Stereoselective Heparan Sulfate Oligosaccharide Assembly.Journal of the American Chemical Society · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
β-Glucuronidation is an important metabolic pathway for a variety of chemicals, including drugs and endogenous substances. We report here that simple (salen)cobalt and (salen)chromium complexes catalyze the β-glucuronidation of alcohols, phenols, and anilines via stereospecific opening of 1,2-anhydroglucuronate electrophiles. The optimized protocol is mild and pH-neutral, enabling the β-glucuronidation of complex pharmaceuticals and natural products bearing acid-sensitive and Lewis-basic functionalities. Kinetic studies reveal a first-order kinetic dependence on catalyst concentration, which stands in contrast to the (salen)metal-catalyzed opening of simple epoxides where second-order rate dependence on the catalyst has been observed consistently.
Identifiers
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Registered trials
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