Evidence map›Paper›PMID 41026514›Full record

ArticleJournal of medicinal chemistry2025

Rigidity vs Activity: Design of Gramicidin S Analogs against Multidrug-Resistant Bacteria Based on Molecular Engineering.

Mikołaj Śleziak, Jarosław J Panek, Tomasz Janek, Aneta Jezierska, Monika Kijewska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Probing theRSC chemical biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mikołaj ŚleziakUniversity of Wrocław, Faculty of Chemistry, F. Joliot-Curie St. 14, Wrocław 50-383, Poland.
Jarosław J PanekUniversity of Wrocław, Faculty of Chemistry, F. Joliot-Curie St. 14, Wrocław 50-383, Poland.ORCID 0000-0002-2952-9739
Tomasz JanekWrocław University of Environmental and Life Sciences, Faculty of Biotechnology and Food Science, Chełmońskiego St. 37, Wrocław 51-630, Poland.
Aneta JezierskaUniversity of Wrocław, Faculty of Chemistry, F. Joliot-Curie St. 14, Wrocław 50-383, Poland.
Monika KijewskaUniversity of Wrocław, Faculty of Chemistry, F. Joliot-Curie St. 14, Wrocław 50-383, Poland.ORCID 0000-0001-6227-7169

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Antimicrobial peptides are a promising class of therapeutics to address antibiotic resistance; yet, their clinical use is limited by toxicity and narrow-spectrum activity. To better understand how conformational rigidity influences efficacy and safety, a series of β-sheet antimicrobial peptide analogs based on gramicidin S were designed and synthesized. Two stapled derivatives (GS

Indexed as

Anti-Bacterial AgentsDrug DesignDrug Resistance, Multiple, BacterialGramicidinGram-Positive BacteriaGram-Negative BacteriaHumansMicrobial Sensitivity TestsMolecular Dynamics SimulationStructure-Activity RelationshipAnti-Bacterial AgentsGramicidin

Identifiers

PMID41026514
PMCPMC12516685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.