ArticleCell biochemistry and biophysics2026
Cytotoxic and Apoptotic Effects of Epipremnum aureum-Mediated Silver Nanoparticles on MCF-7 Breast Cancer Cells.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Systems-Level Analysis of 13-Docosenamide Reveals its Regulatory Role on PPAR, AMPK, and Insulin Pathways in T2DM: In vitro and In silico Approaches.Cell biochemistry and biophysics · 2026Article
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5 authors.
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Abstract
Epipremnum aureum, a traditionally valued medicinal plant, has been investigated for its potential in nanobiotechnology through this research. AgNPs were prepared from the leaf extract of E. aureum through an eco-friendly green synthesis method. The acquired AgNPs were characterized through dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), zeta potential measurement, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDX). SEM & TEM analysis confirmed spherical shape with an average particle size of 151 nanometres. FT-IR spectra revealed functional groups responsible for nanoparticle capping and stabilization, while zeta potential measured at − 34.9 mV indicated high colloidal stability. Plant extracts were obtained through cold maceration using ethyl acetate and chloroform, with the chloroform extract yielding a higher concentration of bioactive compounds. Antioxidant activity, as assessed by DPPH and FRAP assays, demonstrated a superior radical scavenging potential in the chloroform extract. Assessment of cytotoxic activity against MCF-7 cells was performed using both MTT and AO/EtBr dual staining techniques. Biological assays indicated intense dose-dependent activity, with the AgNPs having a considerably smaller IC₅₀ value against MCF-7 breast cancer cells (IC₅₀ = 17 µg/mL) than the crude extract of ethyl acetate (IC₅₀ = 45 µg/mL) and chloroform (IC₅₀ = 38 µg/mL), reflecting greater cytotoxicity. Fluorescence microscopy revealed apoptotic morphological changes in AgNP-treated cells. Additionally, flow cytometric analysis indicated G₂/M phase cell cycle arrest, suggesting a possible mechanism of action for the cytotoxic effects. These findings highlight the potential of Epipremnum aureum-mediated AgNPs as promising candidates for nanomedicine-based breast cancer therapy, offering a sustainable and effective approach for future oncological applications.
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