ArticleBiological trace element research2026
Assessment of Iron's Regulatory Impact on Cadmium Bioavailability in Rice-Based Diets Using a Mouse Model.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The r ole of iron (Fe) in regulating cadmium (Cd) relative bioavailability (Cd-RBA) in dietary rice is unclear, limiting our understanding of health risks from dietary rice consumption, particularly for vulnerable groups like women of reproductive age. Given the health threats from long-term low-dose Cd exposure, this knowledge gap is especially concerning. It is thus important to systematically examine how Cd concentration in dietary rice affects Cd-RBA and to assess the regulatory impact of Fe on Cd-RBA. A mouse experiment was conducted using rice feed with four Cd levels and five Fe levels, and the Cd concentrations in the faces, blood, and urine were determined. Fe addition to rice feed inversely correlated with Cd concentrations in mouse organs. Increasing Fe from 150 to 200 mg/kg significantly reduced Cd concentrations (p < 0.05) and lowered Cd relative bioavailability (RBA). Cd excretion through feces mirrored organ accumulation. Blood Cd levels were very low and inversely proportional to Fe concentration (R
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