Evidence map›Paper›PMID 41026401›Full record

ArticleEpilepsia2026

Anti-γ-aminobutyric acid B receptor autoimmune encephalitis: Clinical presentation and diagnostic insights.

Naveen K Paramasivan, Jennifer A McCombe, Andrea Stabile, James P Fryer, Abhigyan Datta, Mohamed Rezk, Nihar Upadhyay, Jeffrey W Britton, Eoin P Flanagan, Andrew McKeon and 4 more

Abstract read
In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Naveen K ParamasivanDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2185-4385
Jennifer A McCombeDivision of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-9581-5090
Andrea StabileDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-0999-215X
James P FryerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Abhigyan DattaDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2269-546X
Mohamed RezkDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Nihar UpadhyayDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Jeffrey W BrittonDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-0147-8159
Eoin P FlanaganDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6661-2910
Andrew McKeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6856-8143
John R MillsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-1025-4760
Sean J PittockDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6140-5584
Anastasia ZekeridouDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-1960-9065
Divyanshu DubeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6865-9045

Funding

A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis and Assess Markers of DiseaseU01NS120901 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stacey Lynn Clardy · 2021 to 2026
$19.6M
Utilizing epidemiology, imaging and fluid biomarkers in MOG antibody-associated disease to inform prognosis, pathogenesis and therapeuticsR01NS113828 · NINDS · MAYO CLINIC ROCHESTER · PI Eoin P Flanagan · 2020 to 2026
$2.4M
Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep PhenotypingR01NS126227 · NINDS · MAYO CLINIC ROCHESTER · PI Andrew McKeon · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS113828NINDS NIH HHS R01 NS126227NINDS NIH HHS U01 NS120901
6 · The paper itself

Abstract

objectivesγ-Aminobutyric acid B receptor (GABA

methodsPatients testing positive for GABA

resultsEighty-six patients (median age 63 years; 43 female) presented with classic presentations of GABA SIGNIFICANCE: GABA

Indexed as

AutoantibodiesEncephalitisHashimoto DiseaseReceptors, GABA-BAdultAgedAged, 80 and overFemaleFlow CytometryHumansImmunoglobulin GMaleMiddle AgedStatus EpilepticusYoung AdultAutoantibodiesImmunoglobulin GReceptors, GABA-Banti‐GABA‐B receptor autoimmune encephalitisclinical presentationsdiagnostic assaysfalse positivitylive‐cell flow cytometry–based assay

Identifiers

PMID41026401
PMCPMC12599383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.