Evidence map›Paper›PMID 41026388›Full record

ArticleEndocrine2025

To assess the patterns of use of ASA-statin free combinations in primary care: a population-based study in Italy.

Francesco Lapi, Ettore Marconi, Gerardo Medea, Alessandro Rossi, Iacopo Cricelli, Andrea Zanchè, Damiano Parretti, Claudio Cricelli

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco LapiHealth Search, Italian College of General Practitioners and Primary Care, Florence, Italy. lapi.francesco@simg.it.ORCID 0000-0002-4342-9128
Ettore MarconiHealth Search, Italian College of General Practitioners and Primary Care, Florence, Italy.
Gerardo MedeaItalian College of General Practitioners and Primary Care, Florence, Italy.
Alessandro RossiItalian College of General Practitioners and Primary Care, Florence, Italy.
Iacopo CricelliGenomedics SRL, Florence, Italy.
Andrea ZanchèItalian College of General Practitioners and Primary Care, Florence, Italy.
Damiano ParrettiItalian College of General Practitioners and Primary Care, Florence, Italy.
Claudio CricelliItalian College of General Practitioners and Primary Care, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCardiovascular events like heart attacks and strokes can be effectively prevented by ASA (acetylsalicylic acid) and statins. Research indicates that ASA-statins-fixed combinations benefit both primary and secondary cardiovascular event prevention. The primary advantage is enhancing and maintaining medication adherence, a significant concern in cardiovascular disease treatment. We evaluated users of free ASA-statin combinations to quantify adherence levels and identify characteristics of adherent patients. MATERIALS AND

methodsWe formed a cohort of individuals 18 years or older active in a primary care database on December 31, 2022, and prescribed both ASA and statins that year.

resultsOf prevalent and incidence users of ASA-statin therapy, only 31 and 21% were properly adherent, respectively. Higher adherence rates were observed in males (11% more), those with cerebro/cardiovascular diseases (13% more), and patients taking 5 or more concurrent medications (45% more). Conversely, patients with gastrointestinal disorders, heart failure, atrial fibrillation, depression, or asthma/COPD showed significantly lower adherence. Most adherent patients (63-82%) used low-dose statins with ASA.

conclusionsThe findings suggest that adherence among patients using free-ASA-statin combinations is suboptimal. Given the importance of improving medication adherence, it is essential for primary care physicians to devise and implement strategies to enhance and sustain medication adherence, particularly for patients with specific characteristics.

Indexed as

AspirinCardiovascular DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsPrimary Health CareAdultAgedAged, 80 and overDrug CombinationsDrug Therapy, CombinationFemaleHumansItalyMaleMiddle AgedYoung AdultAspirinDrug CombinationsHydroxymethylglutaryl-CoA Reductase InhibitorsASA-statinFixed combinationFree combinationPrimary care

Identifiers

PMID41026388

What OpenQuestion holds

Texttitle and abstract
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.