ArticleEndocrine2025
The effect of dioxin exposure on diabetes and potential dietary modification in the Korean population.
Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThere has been evidence linking dioxin and metabolic disorders, including diabetes. Despite diet being the primary route of dioxin exposure, research assessing dioxin exposure risks using dietary values is still lacking. We aimed to illustrate the risk of dioxin in diabetes by utilizing calculated dioxin dietary intake and blood dioxin concentration values in the Korean population.
methodsThe present study included 202 subjects aged 20–69 undergoing medical evaluations at the Severance health check-up [prediabetes/diabetes (n = 92) vs. control (n = 110)]. Nutritional information for dioxin reduction was provided every month for one year. At baseline and 1-year after points, dioxin concentrations (pg TEQ/g-lipid) in serum were analyzed, and a short version of the food frequency questionnaire with 52 food items was used to calculate dioxin dietary intake.
resultsStrong associations between serum total dioxins, polychlorinated dibenzo-para-dioxins, polychlorinated dibenzofurans, and dioxin-like PCBs (DL-PCBs) concentrations and prediabetes/diabetes risk were observed (all ORs >1.0). Mediation analysis further showed that diastolic blood pressure, high-density lipoprotein-cholesterol, and glucose partially mediated these associations (proportion 11–30%, all p < 0.05). A dietary pattern rich in fish/seafood, meat, eggs, and supplements was positively correlated with serum DL-PCBs in the prediabetes/diabetes group (r = 0.353, p = 0.001). Furthermore, nutrition education has the potential to reduce dioxin dietary intake.
conclusionIf the effectiveness of nutritional education is clearly verified through follow-up research, it can also reduce the risk of dioxin-induced metabolic disorders shown in cross-sectional analyses of baseline data.
Indexed as
Identifiers
41026385What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.