Trial reportDigestive diseases and sciences2026
Uncovering the Mechanisms of Failure of Proton Pump Inhibitors in GERD: The Role of Esophageal Acid Sensitivity.
Trial report in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Esophageal Acid Suppression Unmasks Latent Esophageal Acid-Symptom Phenotypes in GERD.Digestive diseases and sciences · 2026Trial
- Ninety-Six-Hour Ambulatory Esophageal pH Monitoring in Patients with Refractory Acid Reflux Symptoms Off- and On-Proton Pump Inhibition Therapy and Their Response to Anti-reflux Diet.Digestive diseases and sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFor unclear reasons, up to 50% of subjects with gastroesophageal reflux disease have an inadequate symptomatic response to treatment with a proton pump inhibitor. Our primary objective was to examine esophageal acid in subjects who experienced heartburn following a standard meal that failed to respond to a proton pump inhibitor.
methodsWe analyzed data from a previous randomized crossover trial of proton pump inhibitors in 27 subjects with gastroesophageal reflux disease and baseline esophageal pH < 4 for more than 10% of a 24-h recording. Esophageal pH and heartburn severity were measured over 3 h following a standard meal at baseline and after omeprazole.
resultsRelationships between heartburn severity and esophageal acid were identified using the quadrant method. Twelve subjects had high values for heartburn severity with omeprazole, indicating a failed response; 75% of these subjects had low esophageal acid reflecting esophageal hyperalgesia or a cause other than esophageal acid. In subjects with high esophageal acid that failed to improve with omeprazole, heartburn severity improved with omeprazole in 57%, reflecting esophageal hypoalgesia or silent esophageal reflux.
conclusionsFailure of heartburn to respond to omeprazole was common in subjects with gastroesophageal reflux disease who exhibited high baseline esophageal acid exposure and most of these failures were associated with low esophageal acid.
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41026367What OpenQuestion holds
Registered trials
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