Evidence map›Paper›PMID 41026348›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Sleep architecture and quality of life in comorbid OSA and depression: cross-sectional analysis of the Sydney sleep biobank.

Daryl E C Y Chan, Yu Sun Bin, Philip de Chazal, Peter A Cistulli, Andrew S L Chan, John R Wheatley, Kristina Kairaitis, Brendon J Yee

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Daryl E C Y ChanWoolcock Institute of Medical Research, Macquarie University, 2 Innovation Road, Macquarie Park, Sydney, NSW, 2113, Australia. daryl.chan@woolcock.org.au.ORCID 0000-0002-2340-1259
Yu Sun BinSleep Research Group, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Philip de ChazalSchool of Biomedical Engineering, University of Sydney, Sydney, Australia.
Peter A CistulliSleep Research Group, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Andrew S L ChanSleep Research Group, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
John R WheatleyLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia.
Kristina KairaitisLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia.
Brendon J YeeWoolcock Institute of Medical Research, Macquarie University, 2 Innovation Road, Macquarie Park, Sydney, NSW, 2113, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObstructive sleep apnoea (OSA) and depression are individually associated with changes in sleep architecture and reduced quality of life. However, there are few studies which report on the joint impact of comorbid OSA and depression.

methods821 participants from the Sydney Sleep Biobank database were assessed (38% female; age 49.5, SD 15.6 years). Participants were patients who were referred for and underwent an overnight sleep study on suspicion of sleep disordered breathing. Participants were divided into 4 groups based on the apnoea-hypopnoea index and depression score from the Depression Anxiety Stress Scale-21; (1) no OSA-no depression, (2) OSA-only, (3) depression-only, (4) comorbid OSA and depression (OSAD). Sleep architecture and quality of life (Epworth Sleepiness Scale, ESS and Functional Outcomes of Sleep, FOSQ-10) scores were compared between groups. Confounders considered included age, gender, body mass index, alcohol, and psychiatric medications.

resultsPatients with OSAD and depression-only had higher ESS scores (8.4 vs 8.9 vs 6.9, p=0.003) and lower FOSQ-10 scores (13.9 vs 12.8 vs 16.7, p<0.001) than those with OSA-only. However, after control for confounders and excluding patients on psychiatric medications, OSAD was not associated with any significant changes in sleep architecture compared to those with OSA-only. DISCUSSION/

conclusionsDespite the lack of changes in sleep architecture, it is still important to identify comorbid OSA and depression as it can be associated with worse quality of life and this may affect treatment compliance.

Indexed as

DepressionDepressive DisorderQuality of LifeSleep Apnea, ObstructiveAdultAgedComorbidityCross-Sectional StudiesFemaleHumansMaleMiddle AgedDASS-21DepressionEpworth sleepiness scaleFOSQ-10Obstructive sleep apnoeaPolysomnogramQuality of lifeSleep architecture

Identifiers

PMID41026348
PMCPMC12484361

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.