Evidence map›Paper›PMID 41026344›Full record

ArticleBiochemical genetics2026

Tanshinone I Represses Ferroptosis to Protect Against Steroid-Induced Osteonecrosis of the Femoral Head by Activating the Nrf2/SLC7A11 Axis.

Liangyu Lu, Miaomiao Zhou, Xiaolong Zhang, Xiabing Qin

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Liangyu LuOrthopedics Department, Pudong New Area People's Hospital, South Chuanhuan Road, Pudong New Area, Shanghai, 490#201299, China.
Miaomiao ZhouDepartment of Orthopedics 2, the Affiliated Taihe Hospital of Hubei University of Medicine, 32#, Renmin South Road, Shiyan, 442000, Hubei Province, China.
Xiaolong ZhangDepartment of Orthopedics 2, the Affiliated Taihe Hospital of Hubei University of Medicine, 32#, Renmin South Road, Shiyan, 442000, Hubei Province, China.
Xiabing QinDepartment of Orthopedics 2, the Affiliated Taihe Hospital of Hubei University of Medicine, 32#, Renmin South Road, Shiyan, 442000, Hubei Province, China. 15872738587@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to explore how Tanshinone I (TsI) mediates ferroptosis in femur tissue in a rat model of steroid-induced osteonecrosis of the femoral head (SIONFH). Rats were given lipopolysaccharide and methylprednisolone to develop a rat model of SIONFH and treated with 5 mg/kg or 10 mg/kg TsI or in combination with ferroptosis inhibitor Fer-1. After different treatments, bone parameters (BMD, BV/TV, Tb.N, Tb.Th, and Tb.Sp), the levels of osteoblast markers (RUNX2, BGLAP, and Osteopontin proteins), and ferroptosis markers (SLC7A11, GPX4, and ACSL4) in femur tissues were detected; Additionally, ferroptosis indicators Fe

Indexed as

AbietanesAmino Acid Transport System y+Femur Head NecrosisFerroptosisNF-E2-Related Factor 2OsteonecrosisAnimalsMaleMethylprednisoloneRatsRats, Sprague-DawleySignal TransductionAbietanesAmino Acid Transport System y+MethylprednisoloneNfe2l2 protein, ratNF-E2-Related Factor 2tanshinoneFemur tissueFerroptosisGPX4Nrf2SLC7A11Steroid-induced osteonecrosis of the femoral headTanshinone I

Identifiers

PMID41026344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.