ArticleMagma (New York, N.Y.)2026
Evaluation of tractography parameters for dentato-rubro-thalamic tract reconstruction during pediatric posterior fossa tumor surgery.
Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla.Psychiatry and clinical neurosciences · 2026Article
- Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.NMR in biomedicine · 2026Article
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9 authors.
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Abstract
objectiveIntraoperative fiber tractography can help neurosurgeons in localizing eloquent tracts potentially displaced by tumors. In pediatric posterior fossa tumor (pPFT) patients, disturbances to the eloquent dentato-rubro-thalamic tract (DRTT) might contribute to cerebellar mutism syndrome. This study investigates the effect of fiber tractography parameters on DRTT reconstruction in pre- and intraoperative settings.
methodsT1-weighted and diffusion MRI data were acquired from ten pPFT patients and two healthy volunteers. The patients were scanned pre- and intraoperatively. The DRTT was reconstructed using multiple fiber orientation distribution (FOD) and angle thresholds. An expert panel evaluated tract reconstructions to identify optimal parameters in our dataset. The corticospinal tract (CST) served as a control. Relative tract volumes of the DRTT and the CST were calculated.
resultsDiffusion MRI data were sufficient for reliable DRTT reconstruction in healthy volunteers. In most pPFT patients, an FOD of 0.01 and a 60° angle threshold were evaluated as optimal for DRTT reconstruction in our dataset. Preoperative DRTT reconstructions showed more reconstructed streamlines and larger relative volumes, particularly in non-decussating tracts. CST reconstructions remained consistent across both timepoints. DISCUSSION: DRTT reconstruction is feasible in pPFT patients before and during surgery. However, inter-subject variability suggests that some patients may require adjusted thresholds for optimal results.
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