ArticleDiscover oncology2025
Mendelian randomization analyses support causal relationships between unswitched memory B cells and lung squamous cell carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe interaction between immune cells and cancer has been extensively researched. However, little is known about the relationship between B Cells and lung squamous cell carcinoma (LUSC).
methodsThis study performed a comprehensive two-sample Mendelian randomization (MR) analysis of GWAS summary data to determine the causal relationship between the immune phenotypes of 199 subtypes of B cells and the risk of LUSC. Heterogeneity and horizontal pleiotropy were assessed using several methods, including MR-Egger regression and inverse variance weighting.
resultsMR analysis showed that an increase in the absolute count number of unswitched memory B cells (UMBC) was causally associated with the risk of LUSC at FDR < 0.05. Reverse MR analysis indicated that LUSC was causally associated with the increased expression of CD27 on IgD
conclusionThere is a strong association between the number of UMBCs and the risk of LUSC. These results provide a basis for developing new cancer immunotherapies.
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