ArticleAMB Express2025
Antiviral activity of selected plant-derived polyphenols against Varicellovirus bovinealpha1 (BoAHV-1).
Article in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Medicinal plants have been used for centuries in traditional practices to treat a wide range of ailments, including viral infections. Phytochemicals found in these plants represent a promising and largely untapped resource for the development of novel antiviral agents, particularly in light of the limited availability of effective antiviral therapies. This study aimed to evaluate the antiviral potential of five polyphenolic compounds commonly found in medicinal plants: quercetin, rutin, baicalein, (-)-epicatechin, and ethyl gallate against bovine alphaherpesvirus type 1 (BoAHV-1), used as a model for the Orthoherpesviridae family. The cytotoxicity and antiviral activity of the compounds were assessed in vitro using the colorimetric MTT assay. Antiviral effects were quantified based on the concentration required to inhibit 50% of viral replication (IC₅₀). Compounds were tested individually and in combination, with treatments applied before, during, and after viral infection. Expression of the viral gB gene was evaluated using RT-qPCR. Quercetin, rutin, and baicalein exhibited notable antiviral activity, with IC₅₀ values of 16.8 µg mL⁻
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