ArticleClinical oral investigations2025
Response of murine fibroblasts or human keratinocytes to micro- and nano-scale titanium particles: the permeability of particles across keratinocytes' monolayers.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Detection of submicron titanium debris associated with peri-implantitis.Discover nano · 2026Review
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate the cytocompatibility of micro- and nano-scale commercially pure Titanium (cpTi) particles in contact with fibroblasts and keratinocytes and the penetration of cpTi particles across keratinocytes' layers.
methodCommercially pure titanium (cp-Ti) particles with 50-nm or 1-µm size were chemically and morphologically characterized using a Field Emission Guns Electron Microscopy (FEGSEM), Scanning Transmission Electron Microscope (STEM), and Energy Dispersion Spectrometry (EDAX). Then, the cytotoxic profile of the particles was monitored in contact with murine L929 fibroblasts and TR146 keratinocytes for 1, 4, and 7 days. Further permeability assays were performed across a TR146 monolayer via Transwell
resultsPhysicochemical characterization of cpTi nano-scale particles (cpTi NPs) revealed a mean size at 70 nm and a specific surface area at around ~ 17.2 m
conclusionsAltogether, nano-scale titanium particles decreased the viability of fibroblasts although a significant viability of keratinocytes has been detected by standard cell culture assays. However, nano-scale titanium particles were found into keratinocytes and even trespassed the cells' layers that could reach other cells and blood vessels in an in vivo scenario. Thus, toxicity of titanium particles depends on their particle size, exposure time, content, and interaction with the surrounding media.
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