Evidence map›Paper›PMID 41026230›Full record

ArticlePlant cell reports2025

Deciphering the dual resistance pathways to mesosulfuron-methyl in Lolium multiflorum: target-site and non-target-site insights.

Pei Zhang, Xinyang Yuan, Yuqing Liu, Junchuan Song, Runqiang Liu, Hongliang Wang

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Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pei ZhangSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China. zhangpei0519@hist.edu.cn.ORCID http://orcid.org/0009-0007-4297-2990
Xinyang YuanSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Yuqing LiuSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Junchuan SongSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Runqiang LiuSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Hongliang WangSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China. whll@hist.edu.cn.

Funding

High-level Talent Introduction Project of Henan Institute of Science and Technology 2018024Key Research and Development Project of Henan Province 241111111700Postdoctoral research project of Henan Province HN2022121
6 · The paper itself

Abstract

key messageLolium multiflorum exhibits resistance to mesosulfuron-methyl through ALS mutations; HZ2 population also shows metabolic resistance through P450 pathways. Lolium multiflorum L., is a weed that frequently appears in wheat fields and is recognized for its strong competitive nature, where it can cause significant damage to grain production. The weeds of L. multiflorum in the wheat fields may have developed resistance to mesosulfuron-methyl. This study explored the response of L. multiflorum populations in certain areas of Henan Province, China, to mesosulfuron-methyl. The study found that, compared to the HX1 sensitive population, the HZ1 and HZ2 populations showed resistance to mesosulfuron-methyl in the full dose-response test, with resistance ratios of 12.38- and 24.19-fold, respectively. Genetic sequencing revealed novel mutations at the Pro-197-Thr and Asp-376-Glu residues of the ALS gene in both resistant populations. A critical finding was the divergent resistance mechanisms between the geographically close populations, with HZ1 resistance solely conferred by target-site mutations and HZ2 exhibiting multiple resistance driven by both target-site mutations and enhanced metabolism mediated by cytochrome P450 monooxygenases. This was conclusively demonstrated by applying the P450 inhibitors malathion and PBO, which reversed resistance in HZ2 by 66.77% and 70.53%, respectively. Furthermore, both resistant populations showed heightened sensitivity to isoproturon, suggesting a potential management strategy. Molecular docking simulations corroborated that the identified mutations reduce herbicide binding affinity. Our findings provide the first evidence of concurrent target-site and non-target-site resistance to mesosulfuron-methyl in Chinese L. multiflorum, offering crucial insights for diagnosing and managing herbicide resistance.

Indexed as

Herbicide ResistanceHerbicidesLoliumSulfonylurea CompoundsAcetolactate SynthaseChinaMutationPlant ProteinsAcetolactate SynthaseHerbicidesmesosulfuron-methylPlant ProteinsSulfonylurea CompoundsCross-resistanceCytochrome P450Lolium multiflorum L.Multiple-resistanceTarget-site resistance

Identifiers

PMID41026230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.