Evidence map›Paper›PMID 41026197›Full record

ArticleAbdominal radiology (New York)2026

Incorporating new criteria can improve the ability of CEUS LI-RADS to differentiate HCC from non-HCC malignancies.

Rong Wen, Yuting Peng, Ruizhi Gao, Jinshu Pang, Xiumei Bai, Lanhui Qin, Dongyue Wen, Yuquan Wu, Yiqiong Liang, Yun He and 2 more

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Rong WenDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yuting PengDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ruizhi GaoDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jinshu PangDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiumei BaiDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lanhui QinDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Dongyue WenDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yuquan WuDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yiqiong LiangDepartment of Radiology, Guangxi International Zhuang Medicine Hospital, Nanning, China.
Yun HeDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Liling LongDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. cjr.longliling@vip.163.com.
Hong YangDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. yanghong@gxmu.edu.cn.

Funding

China Postdoctoral Science Foundation 2023MD744191Clinical Research Climbing Project of The First Affiliated Hospital of Guangxi Medical University YYZS2020024Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFBA999019
6 · The paper itself

Abstract

purposeThis work aimed to evaluate the diagnostic performance of the CEUS LI-RADS and to further improve its ability to differentiate HCC from non-HCC malignancies by modifying the LR-M criteria.

methodsThis retrospective study included patients with a high risk of HCC who underwent CEUS examination. A subgroup of LR-M lesions was reassessed by applying different diagnostic criteria, including Criterion 1: early washout < 60 s; Criterion 2: Criterion 1 + marked washout within 4 min; Criterion 3: early washout < 45 s; Criterion 4: washout onset-enhancement onset < 30 s. Diagnostic efficacy was assessed.

resultsA total of 1681 liver lesions were included. When LR-5 was used as a predictor of HCC, the sensitivities of Criterion 2 (84.3%), Criterion 3 (73.1%), and Criterion 4 (73.5%) were greater than that of Criterion 1 (67.3%; all p < 0.01). The specificities of Criterion 1 (95.1%), Criterion 3 (94.2%), and Criterion 4 (94.6%) were similar and surpassed that of Criterion 2 (73.5%; all p < 0.01). The PPVs of Criterion 1 (97.7%), Criterion 3 (97.5%), and Criterion 4 (97.7%) were similar and surpassed that of Criterion 2 (95.7%; all p < 0.05).

conclusionThe use of the washout onset time minus the enhancement onset time < 30 s as a new criterion for early washout could help improve the differential ability for HCC and non-HCC malignancies.

Indexed as

Carcinoma, HepatocellularContrast MediaLiver NeoplasmsRadiology Information SystemsAdultAgedAged, 80 and overDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityUltrasonographyContrast MediaContrast-enhanced ultrasoundDiagnostic algorithm optimizationHepatocellular carcinomaLiver imaging reporting and data system

Identifiers

PMID41026197

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