Evidence map›Paper›PMID 41026194›Full record

Observational studyClinical neuroradiology2026

Tmax 10 Volume Is Independently Associated with NWU Delta in Large Core Stroke.

Vivek Yedavalli, Hamza Adel Salim, Dhairya A Lakhani, Aneri Balar, Janet Mei, Thanh N Nguyen, Adrien Guenego, Adam A Dmytriw, Jens Fiehler, Paul Stracke and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Vivek YedavalliDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA. vyedava1@jhmi.edu.
Hamza Adel SalimDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA. Hamza.sleeem@gmail.com.ORCID http://orcid.org/0000-0002-5208-8425
Dhairya A LakhaniDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Aneri BalarDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Janet MeiDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Thanh N NguyenDepartments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA.
Adrien GuenegoDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jens FiehlerDepartment of Radiology, Neuroendovascular Program, University Medical Center Hamburg, Hamburg, Germany.
Paul StrackeDepartment of Radiology, Neuroendovascular Program, University Medical Center Münster, Münster, Germany.
Gabriel BroocksDepartment of Radiology, Neuroendovascular Program, University Medical Center Hamburg, Hamburg, Germany.
Christian HeitkampDepartment of Radiology, Neuroendovascular Program, University Medical Center Hamburg, Hamburg, Germany.
Max WintermarkDepartment of Neuroradiology, MD Anderson Medical Center, 77030, Houston, TX, USA.
Gregory W AlbersDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Jeremy J HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Tobias D FaizyDepartment of Radiology, Neuroendovascular Program, University Medical Center Münster, Münster, Germany.

Funding

NIGMS NIH HHS 5U54GM104942-08
6 · The paper itself

Abstract

backgroundIn patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) and large ischemic cores, there is a need for reliable imaging biomarkers to predict cerebral edema growth. We investigated the association between severely hypoperfused tissue, measured by time-to-maximum greater than 10 s (Tmax > 10 s) volume, and net water uptake (∆NWU) progression.

methodsThis multicenter retrospective cohort study involved AIS-LVO patients with ASPECTS ≤ 5, undergoing EVT at two comprehensive stroke centers between January 2013 and December 2019. We investigated the relationship between Tmax > 10 s volume derived from perfusion imaging and ∆NWU measured on non-contrast head CT images, hypothesizing that larger Tmax > 10 s volumes are indicative of greater edema growth in large core strokes.

resultsA total of 95 patients (median age, 74 years; 55% women) were included. After adjustment for age, sex, glucose, intravenous thrombolysis, admission NIHSS, ASPECTS, Tan collateral score, last known well-to-CT time, and EVT, higher Tmax > 10 s volume (β, -0.34; P = 0.043) and lower ASPECTS (β, -0.30; P = 0.035) were independently associated with greater ∆NWU.

conclusionThe study highlights the importance of considering severe pretreatment hypoperfusion, as reflected by larger Tmax > 10 s volumes, in predicting cerebral edema growth in AIS-LVO patients, which could inform clinical strategies, emphasizing the need for larger prospective studies to validate and explore implications.

Indexed as

Brain EdemaIschemic StrokeTomography, X-Ray ComputedAgedAged, 80 and overDisease ProgressionFemaleHumansMaleRetrospective StudiesCTNet water uptakeNWUPerfusion imagingStrokeTmax

Identifiers

PMID41026194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.