ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mechanoregulative hydrogel enables scar-reduced and functional healing of infected diabetic mobile wounds.Materials today. Bio · 2026Article
- From Smart Hydrogel Design to 4D-Printed Scaffolds: Emerging Paradigms in Precision Drug Delivery and Regenerative Wound Therapy.Gels (Basel, Switzerland) · 2026Review
- Approaching Scarless Wound Healing: From Passive Anti-Fibrotic to Proactive and Programmable Pro-Regenerative Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The wounds at the joints are subject to repeated pulling. This not only causes repeated rupture and bleeding of new granulation tissue, but also causes excessive exogenous mechanical stimulation of cell populations, leading to excessive cell proliferation and vascular proliferation at the trauma site. Inspired by the energy conversion of tendons, the "energy transit station" hydrogel is designed. When applied to dynamic joint wounds, the rigid cross-linked network of hydrogels rapidly absorbs wound edge stress by elastic deformation and stores them as elastic potential energy in the topological network matrix, driving the hydrogels to exhibit programmable elastic recoil capabilities. Thus, the "energy transfer station" hydrogel not only shields stress concentration in sports injuries, but also reprograms energy forms to provide reasonable biomimetic contraction for wounds. In vivo research, compared with the control group (83.06%), this hydrogel can significantly accelerate the healing process of sports injuries (99.87%). The "energy transit station" property significantly downregulated the En1 lineage-positive fibroblast population (only 9.21% of the control group) and coordinated the activation of α-SMA-positive myofibroblasts (only 14.62% of the control group). This research provides an innovative strategy for high-quality healing of joint wounds through the conversion and re-transmission of energy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.