Evidence map›Paper›PMID 41026154›Full record

Trial reportAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity.

Emanuele Pulvirenti, Richard Suphapol Diteesawat, Gaspare Pavei, Valentina Natalucci, Helmut Hauser, Alberto Minetti, Jonathan Rossiter

Abstract readClinical Trial
In one paragraph

Trial report in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuele PulvirentiSchool of Engineering Mathematics and Technology, University of Bristol, Bristol, BS8 1TW, UK.
Richard Suphapol DiteesawatSchool of Engineering Mathematics and Technology, University of Bristol, Bristol, BS8 1TW, UK.
Gaspare PaveiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, 20133, Italy.
Valentina NatalucciDepartment of Pathophysiology and Transplantation, University of Milan, Milan, 20133, Italy.
Helmut HauserSchool of Engineering Mathematics and Technology, University of Bristol, Bristol, BS8 1TW, UK.
Alberto MinettiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, 20133, Italy.
Jonathan RossiterSchool of Engineering Mathematics and Technology, University of Bristol, Bristol, BS8 1TW, UK.ORCID https://orcid.org/0000-0002-9109-9987

Funding

Engineering and Physical Sciences Research Council EP/L015293/1Engineering and Physical Sciences Research Council EP/S021795/1Engineering and Physical Sciences Research Council EP/S026096/1Engineering and Physical Sciences Research Council EP/T020792/1Engineering and Physical Sciences Research Council EP/V062158/1Engineering and Physical Sciences Research Council UKRI142European Space Agency CORA-GBF-2023-011Royal Academy of Engineering CIET1718/22
6 · The paper itself

Abstract

Prolonged exposure to reduced gravity in space leads to bone demineralization and muscle atrophy, which current countermeasures of simple body loading can partially address. To address this aetiology, a resistive hypogravity exosuit (R-HEXsuit) is proposed for dynamic body loading in low gravity. R-HEXsuit is a lightweight (1.4 kg) soft wearable exosuit that uses pneumatic artificial muscles to provide programmed bilateral resistance during walking, stimulating primary leg muscles. Tests on healthy subjects in Earth gravity and simulated Moon gravity reveal that the suit increases metabolic cost by 29.3% in Moon gravity, aligning it with Earth-like metabolic cost. Muscle activation in key knee joint muscles also increases, matching or exceeding Earth levels, without altering natural gait patterns. These results highlight the R-HEXsuit as a promising tool for replicating Earth-like physical demands during low-gravity missions, offering a potential solution for mitigating musculoskeletal degradation in space.

Indexed as

Exoskeleton DeviceGravity SuitsHypogravityMuscle, SkeletalWeight-BearingHumansLower ExtremityMoonSpace FlightWalkingHealth in SpaceHuman spaceflightHypogravityMuscle activationSoft ExosuitsSoft Robotics

Identifiers

PMID41026154
PMCPMC12713045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.