Evidence map›Paper›PMID 41026123›Full record

ArticleJournal of medicinal chemistry2025

Fluorescent Marinoquinoline Derivative as Inhibitors of

Patricia Santos Barbosa, Guilherme Eduardo Souza, Sarah El Chamy Maluf, Vinícius Bonatto, Caio Silva Moura, Giovana Rossi Mendes, Talita Alvarenga Valdes, Yasmin Annunciato, Barbara Dos Santos Rossetto, Priscilla Dantas de Souza Ventura and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Patricia Santos BarbosaChemistry Institute, University of Campinas (UNICAMP), Campinas, São Paulo 13083-970, Brazil.ORCID 0000-0002-0138-3520
Guilherme Eduardo SouzaSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.
Sarah El Chamy MalufSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.ORCID 0000-0002-3050-7473
Vinícius BonattoSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.
Caio Silva MouraDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.
Giovana Rossi MendesSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.
Talita Alvarenga ValdesSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.
Yasmin AnnunciatoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.
Barbara Dos Santos RossettoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.
Priscilla Dantas de Souza VenturaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.
Gilberto Gaspar Duarte OrtinChemistry Institute, University of Campinas (UNICAMP), Campinas, São Paulo 13083-970, Brazil.
Wellington da SilvaChemistry Institute, University of Campinas (UNICAMP), Campinas, São Paulo 13083-970, Brazil.
Marcelo Yudi IcimotoDepartment of Biophysics, Federal University of Sao Paulo, (UNIFESP), Escola Paulista de Medicina, São Paulo, São Paulo CEP 04023-062, Brazil.
Amália Dos Santos FerreiraLeishmaniasis and Malaria Bioassay Platform, Oswaldo Cruz Foundation, Porto Velho, Rondônia 76812-245, Brazil.
Fabio C CruzDepartment of Pharmacology, Federal University of São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, São Paulo 04023-062, Brazil.
Carolina B G TelesLeishmaniasis and Malaria Bioassay Platform, Oswaldo Cruz Foundation, Porto Velho, Rondônia 76812-245, Brazil.
Dhelio B PereiraResearch Center in Tropical Medicine of Rondônia, Porto Velho, Rondônia 76812-245, Brazil.
Gustavo Capatti CassianoGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical, (IHMT), Universidade NOVA de Lisboa (UNL), Lisbon 1099-085, Portugal.
Sofia SantanaGulbenkian Institute for Molecular Medicine, Lisboa 1649-035, Portugal.
Miguel PrudêncioGulbenkian Institute for Molecular Medicine, Lisboa 1649-035, Portugal.ORCID 0000-0003-1746-6029
Camila S BarbosaDepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, São Paulo 04023-062, Brazil.
Igor M R MouraSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.ORCID 0000-0003-3279-6894
Renan Marcel GiampauliBrazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials (LNBio-CNPEM), Campinas, São Paulo 13083-100, Brazil.
Irene Layane De SousaBrazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials (LNBio-CNPEM), Campinas, São Paulo 13083-100, Brazil.ORCID 0000-0002-0894-0545
Silvana Aparecida RoccoBrazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials (LNBio-CNPEM), Campinas, São Paulo 13083-100, Brazil.ORCID 0000-0003-4551-3443
Marcos L GazariniDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.ORCID 0000-0002-3882-6831
Carlos Roque Duarte CorreiaChemistry Institute, University of Campinas (UNICAMP), Campinas, São Paulo 13083-970, Brazil.ORCID 0000-0001-5564-6675
Anna Caroline Campos AguiarDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo 11015-020, Brazil.ORCID 0000-0003-0139-8279
Rafael Victorio Carvalho GuidoSão Carlos of Physics Institute, University of São Paulo (USP), São Carlos, São Paulo 13566-590, Brazil.ORCID 0000-0002-7187-0818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present insights into the mechanism of action of marinoquinolines (MQ), a novel class of lead candidates. Using a divergent synthetic approach, we developed a series of 20 new analogues with fluorescence properties. Structure-activity relationships analysis identified

Indexed as

AntimalarialsFluorescent DyesPlasmodium falciparumQuinolinesAnimalsErythrocytesHumansMalariaMiceParasitic Sensitivity TestsPlasmodium bergheiStructure-Activity RelationshipAntimalarialsFluorescent DyesQuinolines

Identifiers

PMID41026123
PMCPMC12557366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.