ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2025
Association of non-linear dynamics of heart rate variability with all-cause mortality in patients with sarcoidosis.
Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSarcoidosis (Sarc) is linked to increased morbidity and mortality. While 24-hour ambulatory ECG recording is essential for evaluating patients with cardiac symptoms, the complementary role of heart rate variability (HRV) for risk stratification in Sarc patients remains undefined. The aim of this observational study was the assessment of non-linear indices of HRV as independent predictors of mortality in Sarc.
methods317 patients with confirmed diagnosis of Sarc, underwent comprehensive conventional cardiac testing, including Cardiac Magnetic Resonance (CMR) with late gadolinium enhancement (LGE). These patients were followed up for all-cause mortality as endpoint. Each patient underwent twenty-four-hour Holter monitoring, from which approximate entropy (APEN), short and long-term detrended fluctuation analysis (DFAα1 and DFAα2, respectively), as well as other HRV parameters, were calculated.
resultsThe study recruited 317 patients (137 men, 180 women) with a mean age of 48.22 ± 11.88 years. Over a median follow-up period of approximately 48 months, 17 deaths were recorded. Competing risk analysis revealed that decreased DFAα1 was a robust prognostic indicator for increased total mortality. ROC analysis demonstrated that the area under the curve (AUC) of DFAα1 (< 0.95) for predicting mortality was 0.761 (95% confidence interval (CI) = 0.617-0.905). DFAα1 ≥ 0.95 was associated with total mortality (HR = 0.109, 95% CI = 0.033-0.362, P= 0.0003).
conclusionEvaluation of cardiac autonomic dysfunction by DFAα1 serves as an independent predictor for all-cause mortality in patients with Sarc.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.