Evidence map›Paper›PMID 41026019›Full record

ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2025

Particles exposures and sarcoidosis.

Andrew J Ghio, Spencer A Scott, Stephen L Tilley

Abstract read
In one paragraph

Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew J GhioUS Environmental Protection Agency, Research Triangle Park, NC, USA.
Spencer A ScottDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Stephen L TilleyDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcoidosis is a chronic disease characterized by the formation of non-caseating granulomas with the lung being the most frequently involved organ. The current diagnosis of sarcoidosis requires that the etiology be idiopathic with alternative causes of granulomatous disease excluded. The assessment that sarcoidosis has no known cause has been challenged by numerous case reports, case series, and epidemiologic studies supporting associations of this disease with recognized exposures to particles.

objectiveThe literature is reviewed to test for an association between particle exposures and a diagnosis of pulmonary sarcoidosis.

methodsA systematic review of the literature was performed using PubMed/MEDLINE, Web of Science, and TOXNET.

resultsParticles can impact a development of granulomas comparable or identical to those in sarcoidosis patients. Prominent among these particles which participate in a pathogenesis of sarcoidosis are silicas and silicates, metals and metal oxides, and World Trade Center dust.

conclusionsParticle exposure is frequently associated with pulmonary sarcoidosis and should not preclude the diagnosis.

Identifiers

PMID41026019
PMCPMC12536831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.