Evidence map›Paper›PMID 41025902›Full record

ArticleBioanalysis2025

The acute oral toxicity and pharmacokinetic determination of a novel chloroquinoline hybrid molecule by LC-MS/MS.

Monique Labuschagne, Makhotso Lekhooa, Thrineshen Moodley, Chakes Mashaba, Matshawandile Tukulula

Abstract read
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In one paragraph

Article in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monique LabuschagneDSI/NWU Preclinical Drug Development Platform (PCDDP), North-West University, Potchefstroom, South Africa.
Makhotso LekhooaDSI/NWU Preclinical Drug Development Platform (PCDDP), North-West University, Potchefstroom, South Africa.
Thrineshen MoodleyDSI/NWU Preclinical Drug Development Platform (PCDDP), North-West University, Potchefstroom, South Africa.ORCID 0000-0002-7646-3699
Chakes MashabaSchool of Chemistry and Physics, University of Kwa-Zulu Natal, Westville, South Africa.
Matshawandile TukululaSchool of Chemistry and Physics, University of Kwa-Zulu Natal, Westville, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCB-1 is a novel compound evaluated in Sprague Dawley rats to assess its acute oral safety and pharmacokinetic disposition.

objectivesTo determine the short-term oral toxicity of CB-1 and characterize its pharmacokinetic parameters.

methodsAcute oral toxicity was tested at doses up to 100 mg/kg. For pharmacokinetics, six rats received a single 100 mg/kg oral dose. Plasma samples were analyzed using a polar C18 column and quantified by LC - MS/MS monitoring the 490.063→262.00 m/z transition.

resultsNo mortality occurred at 100 mg/kg, indicating acceptable acute safety. CB-1 reached a peak plasma concentration (C

conclusionsCB-1 demonstrated short-term oral safety with rapid absorption, relatively low clearance, and prolonged systemic exposure, likely influenced by enterohepatic recirculation.

Indexed as

QuinolinesTandem Mass SpectrometryAdministration, OralAnimalsChromatography, LiquidLiquid Chromatography-Mass SpectrometryMaleRatsRats, Sprague-DawleyToxicity Tests, AcuteQuinolinesacute oral toxicityLC-MS/MSmethod developmentmethod validationPharmacokinetics

Identifiers

PMID41025902
PMCPMC12667627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.